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Test Code LAB2463 Opiates Confirmation, Random, Urine

Important Note


When an ADRUG scrren tests positive,the laboratory orders this test only if requested by the doctor within 5 days. 


The laboratory orders: OPATU

Additional Codes

Mayo test code: OPATU

Reporting Name

Opiate Confirmation, U

Useful For

Detection and quantification of codeine, hydrocodone, oxycodone, morphine, hydromorphone, oxymorphone, noroxycodone, noroxymorphone, norhydrocodone, dihydrocodeine, and naloxone in urine

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Advisory Information

1. For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order OPATX / Opiates Confirmation, Chain of Custody, Urine.

2. If urine creatinine is required or adulteration of the sample is suspected, order ADULT / Adulterants Survey, Urine.

Specimen Required

Supplies: Aliquot Tube, 5 mL (T465)

Collection Container/Tube: Plastic urine container

Submission Container/Tube: Plastic, 5-mL tube

Specimen Volume: 3 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

Specimen Minimum Volume

2.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reference Values


Cutoff concentrations

Codeine by LC-MS/MS: 25 ng/mL

Dihydrocodeine-by LC-MS/MS: 25 ng/mL

Hydrocodone by LC-MS/MS: 25 ng/mL

Norhydrocodone-by LC-MS/MS: 25 ng/mL

Hydromorphone by LC-MS/MS: 25 ng/mL

Oxycodone by LC-MS/MS: 25 ng/mL

Noroxycodone-by LC-MS/MS: 25 ng/mL

Oxymorphone by LC-MS/MS: 25 ng/mL

Noroxymorphone-by LC-MS/MS: 25 ng/mL

Naloxone-by LC-MS/MS: 25 ng/mL

Morphine by LC-MS/MS: 25 ng/mL

Day(s) and Time(s) Performed

Monday through Friday; Varies

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information



G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
OPATU Opiate Confirmation, U 74760-0


Result ID Test Result Name Result LOINC Value
6543 Codeine-by LC-MS/MS 16250-3
42000 Dihydrocodeine-by LC-MS/MS 19448-0
21177 Hydrocodone-by LC-MS/MS 16252-9
42001 Norhydrocodone-by LC-MS/MS 61422-2
21179 Hydromorphone-by LC-MS/MS 16998-7
21178 Oxycodone-by LC-MS/MS 16249-5
42002 Noroxycodone-by LC-MS/MS 61425-5
35023 Oxymorphone-by LC-MS/MS 17395-5
42003 Noroxymorphone-by LC-MS/MS 90894-7
42004 Naloxone-by LC-MS/MS 77207-9
6542 Morphine-by LC-MS/MS 16251-1
21180 Opiates Interpretation 18390-5

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)


If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.